Lupus & antiphospholipid syndrome
Comorbidity clusters and their relationship with severity and outcomes of index diseases, in a large multicentre systemic lupus erythematosus cohort
Authors' conclusion
Cluster analysis identifies well-differentiated subsets of patients with SLE in terms of their comorbidities. The most relevant comorbidities in SLE tend to aggregate in the most severe patient subsets.
Study context
- Population
- Patients with SLE (ACR-97 criteria) in the retrospective phase of RELESSER (Spanish Society of Rheumatology National Register of SLE); 9.6% men, mean age 45.9 years, 93% Caucasian
- Participants
- 3,658 patients
- Exposure
- Comorbidity clusters compared with one another
- Cluster 1n = 2,336
- Cluster 2n = 516
- Cluster 3n = 418
- Cluster 4n = 388
- Outcome
- Comorbidity clusters (14 cumulative comorbidities)
Methodological detailsmulticentre, unsupervised cluster analysis
- Multicentre
- Unsupervised cluster analysis
Main finding
As reported in the abstract
- Four clusters with markedly different comorbidity profiles and outcomes were identified
- 4
Observational data: associations, not effects.
Original publication
Comorbidity clusters and their relationship with severity and outcomes of index diseases, in a large multicentre systemic lupus erythematosus cohort. Lupus Sci Med. Published 1 July 2025. doi:10.
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