Lupus & antiphospholipid syndrome
SLE Severe Infection Score-Revised (SLESIS-R): an improved score for prediction of serious infection in patients with systemic lupus erythematosus based on the RELESSER prospective cohort
Authors' conclusion
SLESIS-R is an accurate and feasible instrument for predicting infections in patients with SLE.
Study context
- Population
- Patients with systemic lupus erythematosus (SLE) in RELESSER-PROS, the SLE register of the Spanish Society of Rheumatology, with 1 year of follow-up completed (mean age, 49±13 years; 90% women)development cohort
- Participants
- 1,459 patients
- Outcome
- Severe infection (≥1), predicted by SLESIS-R score
- Follow-up
- 1 year
Methodological detailsprospective cohort, multicentre, multivariable logistic model, internal validation by 100-sample bootstrapping
- Prospective cohort
- Multicentre
- Multivariable logistic model
- Internal validation by 100-sample bootstrapping
Performance
As reported in the abstract
SLESIS-R performance for severe infection
- AUROC
- 0.861 (0.777-0.946)
- Score range
- 0 to 17
- Cut-off
- ≥6
- Accuracy at cut-off ≥6
- 85.9%
- Positive likelihood ratio at cut-off ≥6
- 5.48
Further findings
- ≥1 severe infection
- 25 (1.7%)
Original publication
SLESIS-R: an improved score for prediction of serious infection in patients with systemic lupus erythematosus based on the RELESSER prospective cohort. Lupus Sci Med. Published 8 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →