Lupus & antiphospholipid syndrome
Patients with NPSLE experience poorer health-related quality of life (HRQoL) and more fatigue than SLE patients with no neuropsychiatric involvement, irrespective of neuropsychiatric activity
Authors' conclusion
NP in patients with SLE has a detrimental effect on HRQoL experience and is associated with severe fatigue, regardless of the degree of neuropsychiatric disease activity.
Study context
- Population
- Patients with SLE in four phase III trials (BLISS-52, BLISS-76, BLISS-SC, EMBRACE)
- Participants
- 2,968 patients4 phase III trials
- Comparison
- NPSLE vs non-NPSLE
- NPSLEn = 350
- non-NPSLEn = 2,618reference
- Primary endpoint
- HRQoL (SF-36, EQ-5D-3L) and fatigue (FACIT-F)
Methodological detailspooled data (BLISS-52, BLISS-76, BLISS-SC, EMBRACE)
- Pooled data (BLISS-52, BLISS-76, BLISS-SC, EMBRACE)
Primary result
As reported in the abstract
SF-36 physical component summary
NPSLE
35.7
mean · SD 9.1
non-NPSLE
39.6
mean · SD 9.6
P < 0.001
Further findings
Full health state ('no problems' in all EQ-5D dimensions)
P < 0.001
Mean
| Outcome | NPSLE | non-NPSLE | P value |
|---|---|---|---|
| SF-36 mental component summary | 37.3 (SD 12.1) | 41.4 (SD 11.0) | P < 0.001 |
| Fatigue (FACIT-F) | 23.8 (SD 12.2) | 31.5 (SD 11.6) | P < 0.001 |
- EQ-5D dimensions
- P < 0.05 for all
EQ-5D dimensions
- NPSLE impaired HRQoL in all EQ-5D dimensions vs non-NPSLE
Active vs inactive NPSLE (SF-36, EQ-5D, full health state (FHS), FACIT-F)
- No discernible distinctions between active and inactive NPSLE
Original publication
Patients with NPSLE experience poorer HRQoL and more fatigue than SLE patients with no neuropsychiatric involvement, irrespective of neuropsychiatric activity. Rheumatology (Oxford). Published 5 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →