Lupus & antiphospholipid syndrome
Effect of systemic lupus erythematosus on the ovarian reserve: A systematic review and meta-analysis
Authors' conclusion
The impact of SLE on ovarian reserve is significant, and the effect may be particularly severe in cases of adult-onset SLE.
Study context
- Population
- Females with Systemic Lupus Erythematosus (SLE) vs healthy individuals; studies comparing ovarian reserve
- Participants
- 1,017 females13 studies
- Comparison
- SLE vs healthy individuals
- Outcome
- Ovarian reserve: AMH, AFC and FSH
Pooled result
As reported in the abstract
Ovarian reserve (AMH, AFC, FSH)
Each group vs healthy individualsEstimate (95% CI)P value
SLE
WMD (AMH) −1.07(−1.37 to −0.76)
P < 0.001SLE
WMD (AFC) −3.46(−4.57 to −2.34)
P < 0.001Further pooled results
| Outcome | Estimate | P value | |
|---|---|---|---|
| Adult-onset SLE (subgroup): AMH, AFC, FSHSLEvs Healthy individualsAdult-onset | WMD (AMH) −1.44 (95% CI −1.71 to −1.18) | P < 0.001 | |
| Adult-onset SLE (subgroup): AMH, AFC, FSHSLEvs Healthy individualsAdult-onset | WMD (AFC) −3.11 (95% CI −3.60 to −2.61) | P < 0.001 | |
| Adult-onset SLE (subgroup): AMH, AFC, FSHSLEvs Healthy individualsAdult-onset | WMD (FSH) 0.60 (95% CI 0.15–1.05) | P < 0.01 | |
| Juvenile-onset SLE (subgroup): AMH, AFC, FSHJuvenile-onset | WMD (AFC) −7.27 (95% CI −12.39 to −2.14) | P < 0.01 | |
| −15−10−505Difference (linear scale) |
Juvenile-onset SLE (subgroup): Anti-müllerian hormone (AMH), antral follicle count (AFC), follicle-stimulating hormone (FSH)
- No significant differences in AMH and FSH levels
Original publication
Effect of systemic lupus erythematosus on the ovarian reserve: A systematic review and meta-analysis. Joint Bone Spine. Published 3 April 2024. doi:10.
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