Lupus & antiphospholipid syndrome
Investigating the association between antiphospholipid syndrome and ovarian reserve: A systematic review and meta-analysis of the literature
Authors' conclusion
The results of this meta-analysis identified there is no relationship between primary and secondary APS with the reduction of ovarian reserves in women with APS.
Study context
- Population
- Women with antiphospholipid syndrome (APS), studies investigating the effect of APS on ovarian reserveFour cross-sectional studies
- Comparison
- APS vs controls, ovarian reserve
- Outcome
- Ovarian reserve (antimullerian hormone amounts)
Methodological detailsrandom effects model, None of the studies had a high risk of bias
- Random effects model
- None of the studies had a high risk of bias
Pooled result
As reported in the abstract
Antimullerian hormone amounts
Estimate (95% CI)P value
Primary APS
MD −0.27(−1.42 to 0.87)
P = 0.639Secondary APS
SMD −0.38(−2.46 to 1.69)
P = 0.717Further pooled results
Antral follicle count (AFC)
- Lower AFC in women with primary APS (2 studies)
Serum gonadotropins and estradiol
- Results contradictory
Original publication
Investigating the association between antiphospholipid syndrome and ovarian reserve: A systematic review and meta-analysis of the literature. Lupus. Published 1 April 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →