Lupus & antiphospholipid syndrome
Efforts to Better Characterize “Antiphospholipid Antibody Nephropathy” for the 2023 ACR/EULAR Antiphospholipid Syndrome Classification Criteria: Renal Pathology Subcommittee Report
Authors' conclusion
Our results support the inclusion of aPL-N in the 2023 American College of Rheumatology/European Alliance of Associations for Rheumatology APS CC, and provide the most widely accepted terminology to date for both acute and chronic pathologic lesions of aPL-N.
Study context
- Population
- Worldwide antiphospholipid syndrome (APS) physicians, published literature, renal biopsy reports from an international patient registry, and international Renal Pathology Society (RPS) members
- Outcome
- Characterisation of aPL nephropathy (aPL-N)
Methodological detailsDelphi surveys, literature review and meta-analysis, registry biopsy report review, expert survey, international patient registry, RPS member survey
- Delphi surveys, literature review and meta-analysis, registry biopsy report review, expert survey
- International patient registry
- RPS member survey
Recommendations
As reported in the abstract
- Meta-analysis demonstrated an association between nephropathy and aPL
- Preliminary aPL-N definition: acute lesions (thrombotic microangiopathy in glomeruli or arterioles/arteries) and chronic lesions (organized arterial or arteriolar microthrombi with or without recanalization, organized glomerular thrombi, fibrous and fibrocellular [arterial or arteriolar] occlusions, focal cortical atrophy with or without thyroidization, fibrous intimal hyperplasia)
- Most RPS survey respondents agreed with this terminology and the importance of knowing aPL results for histopathological diagnosis
Original publication
Efforts to Better Characterize “Antiphospholipid Antibody Nephropathy” for the 2023 ACR/EULAR Antiphospholipid Syndrome Classification Criteria: Renal Pathology Subcommittee Report. J Rheumatol. Published 1 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →