Lupus & antiphospholipid syndrome
Serum NLRC3 levels in systemic lupus erythematosus: correlation with clinical characteristics
Authors' conclusion
Serum NLRC3 levels are significantly reduced in active SLE patients and are associated with clinical disease activity parameters.
Study context
- Population
- Newly diagnosed active systemic lupus erythematosus (SLE) patients hospitalised at Meizhou People's Hospital, January 2023–May 2024, with lupus low disease activity state (LLDAS) SLE patients and healthy controls
- Participants
- 60 / 60 / 50
- Exposure
- Active SLE vs LLDAS SLE vs healthy controls
- Active SLEn = 60
- LLDAS SLEn = 60
- Healthy controls (HCs)n = 50reference
- Outcome
- Serum NLRC3 levels and their correlations with disease characteristics in SLE
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Serum NLRC3 levels
- Active SLE vs LLDAS SLE: P = 0.014
- Active SLE vs HCs: P = 0.004
- LLDAS SLE vs HCs: P = 0.631
Observational data: associations, not effects.
Further findings
NLRC3 levels in active SLE by clinical features
- Significantly lower with fever
- P = 0.029
- Significantly lower with rash
- P = 0.034
- Significantly lower with haematological involvement
- P = 0.032
Spearman correlations of NLRC3 with clinical characteristics
- Negative correlation with fever
- P = 0.028
- Negative correlation with rash
- P = 0.033
- Negative correlation with leukopenia
- P = 0.028
- Negative correlation with serum BAFF
- P = 0.017
- Positive correlation with complement C3
- P = 0.044
Diagnostic performance of NLRC3 for discriminating active SLE from LLDAS SLE (ROC)
- AUC
- 0.665
- P
- P = 0.003
Original publication
Serum NLRC3 levels in systemic lupus erythematosus: correlation with clinical characteristics. Clin Exp Rheumatol. Published 31 March 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →