Lupus & antiphospholipid syndrome
Serum C-reactive protein levels can predict organ damage in patients with systemic lupus erythematosus (SLE) with the lupus low disease activity state
Authors' conclusion
CRP levels were associated with SDI progression in younger patients with LLDAS.
Study context
- Population
- Patients with SLE meeting lupus low disease activity state (LLDAS) criteria at registration
- Participants
- 276 patients
- Exposure
- Serum C-reactive protein (CRP) consistently >1.0 mg/L vs ≤1.0 mg/L at registration and first year
- High CRPn = 81
- Low CRPn = 195reference
- Outcome
- Damage accrual: increase in SLICC/ACR DI (SDI)
Main finding
As reported in the abstract
SDI progression (damage accrual)
CRP categories not associated with SDI progression
HR: 1.40, 95% CI: 0.85-2.31
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| SDI progression in younger patients (subgroup) | 2.91 (1.21–7.03) | P = 0.017 | |
| 0.10.31310Hazard ratio (log scale) |
SDI progression, older age
- Older patients more likely to experience damage accrual: HR 1.03 (95% CI 1.01-1.05), p = 0.002
Original publication
Serum C-reactive protein levels can predict organ damage in patients with SLE with the lupus low disease activity state. Lupus. Published 28 July 2026. doi:10.
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