Lupus & antiphospholipid syndrome
Balancing stringency and feasibility: comparative value of disease-activity measures to predict pregnancy outcomes in systemic lupus erythematosus
Authors' conclusion
SLE-DAS LDA effectively predicts maternal complication, while LLDAS better identifies fetal risk.
Study context
- Population
- Pregnant women with SLE managed at Shenzhen People's Hospital, January 2017–December 2024202 pregnancies in 196 women
- Exposure
- Preconception SLE-DAS LDA, lupus low disease activity state (LLDAS) and SLE-DAS remission vs Definitions of Remission in SLE (DORIS) remission in predicting pregnancy outcomes
- Outcome
- Maternal flares and fetal outcomes (spontaneous abortion, therapeutic abortion, total fetal loss, preterm delivery, SGA)
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
- SLE-DAS LDA vs higher disease activity: maternal flares
- 22.1% vs 45.1%
- SLE-DAS LDA vs higher disease activity: therapeutic abortions
- 6.4% vs 15.7%
- LLDAS vs higher disease activity: flare
- 21.3% vs 45.3%
- LLDAS vs higher disease activity: therapeutic abortion
- 7.9% vs 17.3%
- LLDAS vs higher disease activity: total fetal loss
- 19.7% vs 34.2%
- LLDAS vs higher disease activity: preterm delivery
- 22.0% vs 25.3%
- DORIS remission vs higher disease activity: total fetal loss
- 15.4% vs 31.5%
- DORIS remission vs higher disease activity: preterm delivery
- 15.4% vs 28.2%
- DORIS remission vs higher disease activity: Small for gestational age (SGA)
- 9.0% vs 19.4%
Observational data: associations, not effects.
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Balancing stringency and feasibility: comparative value of disease-activity measures to predict pregnancy outcomes in systemic lupus erythematosus. Lupus Sci Med. Published 22 January 2026. doi:10.
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