Lupus & antiphospholipid syndrome
Comparative performance of lupus disease-activity indices during pregnancy to predict adverse obstetric outcomes: A colombian SLE cohort
Authors' conclusion
In this small single-center cohort, active lupus was associated with adverse obstetric outcomes across disease-activity instruments.
Study context
- Population
- Pregnancies in women with SLE, tertiary center in Bogotá, Colombia (2012–2024)pregnancies (28 women)
- Participants
- 29 pregnancies
- Exposure
- Five lupus disease-activity indices (SLEPDAI, Lupus Activity Index in Pregnancy (LAI-P), modified SLAM (m-SLAM), SLE Disease Activity Score (SLE-DAS), BILAG2004-P) for discriminating a composite adverse obstetric outcome
- Outcome
- Discrimination of composite adverse obstetric outcome:
- Preterm birth
- Miscarriage
- Stillbirth/early fetal death
- Preeclampsia/eclampsia
- Premature rupture of membranes
- Postpartum hemorrhage
- Thromboembolism
- Placental abruption
- Maternal death
Methodological detailssingle-centre, tertiary center, one retrospective assessment per pregnancy with complete data, exploratory categorical and renal-item analyses
- Single-centre
- Tertiary center
- One retrospective assessment per pregnancy with complete data
- Exploratory categorical and renal-item analyses
Main finding
As reported in the abstract
Discrimination of composite AO by continuous index scores
AO occurred in 18/29 pregnancies
62.1%
Observational data: associations, not effects.
Further findings
AO by categorical activity thresholds (exploratory) · exploratory
Threshold BILAG2004-P any A/B domain · SLEPDAI ≥3 · SLE-DAS >7.64
| Outcome | OR (95% CI) | |
|---|---|---|
| AO by renal activity items (exploratory)BILAG2004-P renal A/Bvs No BILAG2004-P renal A/B13/14 vs 5/15 · exploratory | 26.0 (2.61–259.31) | |
| AO by renal activity items (exploratory)SLEPDAI renal-item score >0vs SLEPDAI renal-item score 013/13 vs 5/16 · exploratory | 56.45 (2.81–1133.97) | |
| AO by renal activity items (exploratory)LAI-P renal item >0vs LAI-P renal item 012/13 vs 6/16 · exploratory | 20.00 (2.05–195.01) | |
| 0.050.21520Odds ratio (log scale) |
Original publication
Comparative performance of lupus disease-activity indices during pregnancy to predict adverse obstetric outcomes: A colombian SLE cohort. Lupus. Published 10 June 2026. doi:10.
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