Lupus & antiphospholipid syndrome
Risk of adverse pregnancy outcomes prior to the onset of an autoimmune rheumatic disease: a systematic review
Authors' conclusion
Our findings of an increased risk of APO in certain pre-ARDs highlights the relevance of taking an obstetric history during the first rheumatology appointment and the need for novel screening strategies for the prediction of APOs.
Study context
- Population
- Women with preclinical autoimmune rheumatic disease (ARD) (preclinical ARD (pre-ARD)) before diagnosis of an ARD many years post-partum27 original articles
- Comparison
- Pregnancies preceding diagnosis of ARD (pre-SLE, pre-RA) vs GenPop pregnancies and pregnancies of women with SLE
- Outcome
- Adverse pregnancy outcomes (APO)
Methodological detailsPRISMA, PubMed database, 176 articles screened
- PRISMA
- PubMed database
- 176 articles screened
Pooled result
As reported in the abstract
APO
- Pre-SLE: increased burden of poor pregnancy outcomes vs GenPop
- Pre-SLE: fewer adverse pregnancy outcome (APOs) vs pregnancies of women with SLE
- Pre-RA: similar rate of APOs vs GenPop
- Pre-RA: 15 studies, >1600 pregnancies
- Pre-SLE: 14 studies, >1000 pregnancies
Original publication
Risk of adverse pregnancy outcomes prior to the onset of an autoimmune rheumatic disease: a systematic review. Rheumatology (Oxford). Published 5 August 2022. doi:10.
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