Lupus & antiphospholipid syndrome
Clinical, Histologic, and Serological Predictors of Renal Function Loss in Lupus Nephritis
Authors' conclusion
Low baseline eGFR and chronic histologic damage, but not activity or ISN class, predicted eGFR loss. Proteinuria <0.7 g/g at one year was associated with better outcomes but did not ensure protection.
Study context
- Population
- Lupus nephritis (LN) patients in the Accelerating Medicines Partnership LN longitudinal cohort
- Participants
- 172 patients
- Outcome
- Kidney function loss (sustained ≥40% eGFR decline or progression to end-stage kidney disease)
- Follow-up
- Median 4.6 years (range 0.5-7.8)
Methodological detailslongitudinal cohort, time-to-event analyses, centrally scored histology
- Longitudinal cohort
- Time-to-event analyses
- Centrally scored histology
Main finding
As reported in the abstract
Kidney function loss · median follow-up 4.6 years
Kidney function loss occurred
57 of 172
33%
Observational data: associations, not effects.
Further findings
Proteinuria at 12 months
- Urine protein-to-creatinine ratio <0.7 g/g associated with lower risk; no single threshold ensured protection, lower levels had better outcomes
Clinical response at 3, 6 or 12 months
- Lack of complete clinical response predicted future eGFR loss; partial response conferred intermediate risk
Serological markers
- Not associated with eGFR loss
Original publication
Clinical, Histologic, and Serological Predictors of Renal Function Loss in Lupus Nephritis. Arthritis Care Res (Hoboken). Published 9 June 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →