Lupus & antiphospholipid syndrome
Extrarenal symptoms associate with worse quality of life in patients enrolled in the AMP RA/SLE Lupus Nephritis Network
Authors' conclusion
Most patients had isolated renal disease and extrarenal manifestations associated with worse HRQOL.
Study context
- Population
- Lupus nephritis (LN) patients consecutively enrolled in the multicentre Accelerating Medicines Partnership, at a clinically indicated renal biopsy
- Participants
- 181 participants
- Exposure
- LN with extrarenal disease vs isolated renal disease
- Extrarenaln = 75
- Isolated renaln = 106reference
- Outcome
- PROMIS-29 standardized T scores (health-related quality of life (HRQOL))
- Follow-up
- Time of clinically indicated renal biopsy
Methodological detailsmulticentre, multi-ethnic/racial, consecutive enrolment
- Multicentre
- Multi-ethnic/racial
- Consecutive enrolment
Main finding
As reported in the abstract
PROMIS-29 HRQOL domains
- Extrarenal vs isolated renal: significantly worse pain interference, ability to participate in social roles, physical function, and fatigue
- Extrarenal: PROMIS-29 scores differed significantly from general population by >0.5 SD of reference mean in pain interference, physical function, and fatigue
Observational data: associations, not effects.
Further findings
Most common extrarenal manifestations
- Rash
- 45%
- Arthritis
- 40%
- Alopecia
- 40%
Association of manifestations with scores
- Arthritis most strongly associated with worse pain interference, physical function and fatigue scores
Original publication
Extrarenal symptoms associate with worse quality of life in patients enrolled in the AMP RA/SLE Lupus Nephritis Network. Rheumatology (Oxford). Published 26 March 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →