Lupus & antiphospholipid syndrome
SLE disease activity score (SLE-DAS) remission and low disease activity were similarly associated with patient-reported outcomes compared with definition of remission in SLE remission and lupus low disease activity state
Authors' conclusion
Remission and LDA criteria based on the safety of oestrogens in lupus erythematosus national assessment SLE disease activity index and SLE-DAS exhibited similar associations with PROs.
Study context
- Population
- Patients with SLE visiting Juntendo University and affiliated hospitals, 2018–2024
- Participants
- 334 patients
- Exposure
- Definition of remission in SLE (DORIS) remission, SLE-DAS remission, lupus low disease activity state (LLDAS) and SLE-DAS low disease activity (LDA) in relation to patient-reported outcomes (PROs)
- Outcome
- Association of remission/LDA criteria with PROs (SF-36, EuroQol-5D)
Methodological detailsmulticentre, prospective, cross-sectional analysis, multivariate analyses
- Multicentre
- Prospective
- Cross-sectional analysis
- Multivariate analyses
Main finding
As reported in the abstract
Association with PROs
- All remission and LDA criteria significantly associated with SF-36 physical component summary
- SLE-DAS remission showed superior accuracy metrics vs DORIS remission
- No associations with mental component summary for any remission or LDA criteria
- EuroQol-5D: no correlations with DORIS remission; correlations with other remission and LDA criteria
Observational data: associations, not effects.
Original publication
SLE-DAS remission and low disease activity were similarly associated with patient-reported outcomes compared with definition of remission in SLE remission and lupus low disease activity state. Rheumatology (Oxford). Published 25 June 2025. doi:10.
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