Lupus & antiphospholipid syndrome
Serum glutathione reductase level as a disease activity biomarker in systemic lupus erythematosus: a single-centre preliminary study
Authors' conclusion
Serum GR levels are positively correlated with SLE disease activity and exhibit clinical value in identifying moderate-to-severe disease activity in SLE.
Study context
- Population
- Patients with SLE and healthy controls142 SLE, 100 healthy controls
- Comparison
- Serum glutathione reductase (GR) vs C3 and C4 as markers of SLE disease activity
- Outcome
- Association of serum GR levels with SLE disease activity (SLEDAI 2000, SLE-DAS)
Methodological detailssingle-centre, preliminary
- Single-centre
- Preliminary
Performance
As reported in the abstract
Correlation with SLE disease activity (Spearman ρ)
| Test or model | ρ with SLEDAI 2000 | ρ with SLE Disease Activity Score (SLE-DAS) |
|---|---|---|
| GR | 0.335 | 0.454 |
| C3 | −0.544 | −0.290 |
| C4 | −0.418 | −0.242 |
ρ with SLEDAI 2000
GR0.335
C3−0.544
C4−0.418
ρ with SLE Disease Activity Score (SLE-DAS)
GR0.454
C3−0.290
C4−0.242
Further findings
AUC
GR
0.700(95% CI: 0.617 to 0.774)
C3
0.784(95% CI: 0.707 to 0.848)
C4
0.697(95% CI: 0.615 to 0.771)
- GR AUC comparable to C3 and C4
AUC
GR
0.767(95% CI: 0.689 to 0.834)
C3
0.661(95% CI: 0.576 to 0.738)
C4
0.617(95% CI: 0.532 to 0.698)
- GR equal to C3 but superior to C4
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Serum glutathione reductase level as a disease activity biomarker in systemic lupus erythematosus: a single-centre preliminary study. Lupus Sci Med. Published 24 June 2025. doi:10.
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