Lupus & antiphospholipid syndrome
Potential protective role of high Mediterranean diet adherence for systemic lupus erythematosus: mediation by liver and kidney function biomarkers in the UK Biobank cohort
Main finding · SLE riskResult — go to the resultHazard ratio 0.61 95% CI 0.374–0.995Authors' conclusion
High adherence to the MD is significantly associated with a reduced risk of developing SLE. This beneficial effect may be partially mediated by improvements in liver and kidney function biomarkers
Study context
- Population
- UK Biobank participants free of SLE at baseline127 SLE cases
- Participants
- 203,119 participants
- Exposure
- High and moderate vs low adherence to the Mediterranean diet
- Outcome
- Incident SLE
Methodological detailsCox proportional hazards regression, mediation analysis
- Cox proportional hazards regression
- Mediation analysis
Main finding
SLE risk · median follow-up 10.6 years
Hazard ratio
0.61
95% CI 0.374–0.995
High and moderatevs low adherence to the Mediterranean diet (MEDAS score)
HR 0.61 (95% CI 0.374–0.995)
As reported in the abstract
Observational data: associations, not effects.
Further findings
Mediation by liver and kidney function biomarkers
- Mediation proportions
- 0.32% to 4.61%
- Protective effect might be partially mediated
Original publication
Potential protective role of high Mediterranean diet adherence for systemic lupus erythematosus: mediation by liver and kidney function biomarkers in the UK Biobank cohort. Rheumatology (Oxford). Published 24 June 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →