Lupus & antiphospholipid syndrome
Beneficial effects associated to a healthy lifestyle in systemic lupus erythematosus: A cross-sectional study
Authors' conclusion
A healthy lifestyle, especially physical activity is associated with beneficial effects including quality of life, depression and fatigue in SLE.
Study context
- Population
- Systemic lupus erythematosus (SLE) patients (44.3 ± 31.7 years, 87.6% female)
- Participants
- 145 patients
- Exposure
- Healthy lifestyle vs no healthy lifestyle in SLE
- Healthy lifestylen = 49
- Outcome
- SLE health domains (healthy vs no healthy lifestyle), independent of SLE disease activity
Methodological detailslinear regression modeling, Wilcoxon's signed-rank test
- Linear regression modeling
- Wilcoxon's signed-rank test
Main finding
As reported in the abstract
Β (physical quality of life, PCS)
4.5
95% CI 1.5–7.9P = 0.01
Healthy lifestyle
Β (depression)
−5.0
95% CI −8.2 to −0.2P = 0.02
Healthy lifestyle
Β (fatigue)
−0.8
95% CI −1.5 to −0.2P = 0.01
Healthy lifestyle
Observational data: associations, not effects.
Further findings
dsDNA-antibodies
P = 0.049
Per 1,000 kcal of weekly physical activity energy expenditure (PAEE)
- PCS point increase 1.8 (0.9-2.6), p = 0.0001
- CES-D point decrease 0.2 (0.03-0.4), p = 0.01
- FFbH point increase 2.8 (1.2-4.4), p = 0.0006
- Physical activity had the highest impact on health domains vs smoking or diet adherence, consistent after adjusting for multiple potential confounders
Original publication
Beneficial effects associated to a healthy lifestyle in systemic lupus erythematosus: A cross-sectional study. Lupus. Published 11 May 2023. doi:10.
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