Lupus & antiphospholipid syndrome
Increased frequency of hospital admissions with active systemic lupus erythematosus disease activity defined by two different disease activity indices: A cohort study
Authors' conclusion
In conclusion, disease activity defined by the SLE-DAS, but not SLEDAI-2K was associated with an increased frequency of SLE-related hospitalization.
Study context
- Population
- Adult patients with SLE, rheumatology outpatient department of a regional hospital in southern Taiwan
- Exposure
- Moderate/severe vs lower SLE disease activity, defined by Systemic Lupus Erythematosus Disease Activity Score (SLE-DAS) and by SLEDAI-2K
- Outcome
- Frequency of hospital admissions (all-cause and SLE-related)
Methodological detailssingle regional hospital, generalized linear model with gamma distribution and log-linked function, Cause of admission identified by a rheumatologist from medical records
- Single regional hospital
- Generalized linear model with gamma distribution and log-linked function
- Cause of admission identified by a rheumatologist from medical records
Main finding
As reported in the abstract
Frequency of hospital admissions
Mean frequency of all-cause hospitalization (times per year)
0.34
Mean frequency of SLE-related admission (times per year)
0.21
Observational data: associations, not effects.
Further findings
SLE-related admissions, model including steroid dosage
- Moderate/severe activity by SLE-DAS remained significantly associated with SLE-related admissions
- P = 0.032
Other factors associated with admission frequency
- Steroid dosage, lower educational level and smoking associated with increased frequency
- Underweight and alcohol use associated with decreased frequency
Original publication
Increased frequency of hospital admissions with active systemic lupus erythematosus disease activity defined by two different disease activity indices: A cohort study. Lupus. Published 10 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →