Lupus & antiphospholipid syndrome
Glomerular mTORC1 activation was associated with podocytes to endothelial cells communication in lupus nephritis
Authors' conclusion
Glomerular mTORC1 was highly activated in patients with both glomerular endocapillary hypercellularity and podocyte injury, which might be involved in podocytes to endothelial cells communication in lupus nephritis.
Study context
- Population
- Patients with lupus nephritis (LN); renal biopsy specimens (formalin-fixed paraffin-embedded kidney tissues)176 LN patients in validation
- Participants
- 10 vs 3
- Comparison
- LN with severe vs non-severe endothelial-podocyte injury
- Severen = 10
- Non-severen = 3reference
- Outcome
- Kidney protein expression and glomerular mTORC1 activation
Methodological detailsquantitative proteomics (label-free liquid chromatography-mass spectrometry), Gene Ontology (GO) enrichment analysis, validation cohort
- Quantitative proteomics (label-free liquid chromatography-mass spectrometry)
- GO enrichment analysis
- Validation cohort
Main finding
As reported in the abstract
- Proteins upregulated in severe vs non-severe
- 230
- Proteins downregulated in severe vs non-severe
- 54
- Correlation of glomerular mTORC1 activation with endocapillary hypercellularity (r)
- r=0.289, p<0.001
- Glomerular mTORC1 activation significantly increased in patients with both endocapillary hypercellularity and foot process width (FPW) >1240 nm
- p<0.001
Original publication
Glomerular mTORC1 activation was associated with podocytes to endothelial cells communication in lupus nephritis. Lupus Sci Med. Published 5 May 2023. doi:10.
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