Lupus & antiphospholipid syndrome
Increased risk of hospital admissions in patients with active systemic lupus erythematosus (SLE) classified according to two different SLE disease activity indices: a prospective cohort study
Authors' conclusion
In this study, SLE disease activity classified by SLE-DAS was significantly associated with an increased risk for both all-cause and SLE-related hospital admissions.
Study context
- Population
- Adult patients with SLE from the rheumatology outpatient department of a regional hospital in southern Taiwancompleted the study
- Participants
- 326 patients
- Exposure
- Moderate/severe vs lower SLE disease activity classified by Systemic Lupus Erythematosus Disease Activity Score (SLE-DAS) or SLEDAI-2K
- Outcome
- All-cause and SLE-related hospital admission
- Follow-up
- Within one year
Methodological detailsCox regression
- Cox regression
Main finding
As reported in the abstract
Risk of SLE-related and all-cause hospital admission by moderate/severe disease activity
SLE-related admission, moderate/severe activity by SLE-DAS: HR
2.43
p=0.005
SLE-related admission, moderate/severe activity by SLEDAI-2K: HR
1.84
p=0.057
All-cause admission, moderate/severe activity by SLE-DAS: HR (only SLE-DAS significantly associated)
1.94
p=0.016
Observational data: associations, not effects.
Further findings
Hospital admission incidence (all patients) · within one year
- All-cause admission
- 17.5%
- SLE-related admission
- 12.6%
Adjustment for steroid dosage
- When steroid dosage was considered, only steroid dosage was significantly associated with all-cause and SLE-related admissions
Original publication
Increased risk of hospital admissions in patients with active systemic lupus erythematosus (SLE) classified according to two different SLE disease activity indices: a prospective cohort study. Clin Exp Rheumatol. Published 14 March 2022. doi:10.
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