Lupus & antiphospholipid syndrome
Anti-SSA/Ro positivity and congenital heart block: obstetric and foetal outcome in a cohort of anti-SSA/Ro positive pregnant patients with and without autoimmune diseases
Authors' conclusion
Our data suggest that anti-SSA/Ro positive patents with a de ned systemic autoimmune disease undergoing a strict follow-up since positive pregnancy test display a low risk of pregnancy complications, including but not limited to NL.
Study context
- Population
- Anti-SSA/Ro positive pregnant women with or without systemic autoimmune diseases, 2010 to 2020
- Participants
- 258 women322 pregnancies
- Exposure
- Anti-SSB/La+ vs Anti-SSB/La−
- Outcome
- Prevalence of CHB
Methodological detailsMonthly visits and weekly (16th-24th week) foetal heart rate assessment by obstetric US
- Monthly visits and weekly (16th-24th week) foetal heart rate assessment by obstetric US
Main finding
As reported in the abstract
Congenital congenital heart block (CHB) cases (7 complete, 1 II-III degree, 1 first degree)
9
2.8%
CHB in pregnancies followed from beginning of pregnancy (314); 1 case in anti-SSA/Ro+ asymptomatic subject
1
0.3%
Observational data: associations, not effects.
Further findings
CHB by anti-SSB/La positivity
P = 0.0071
Maternal and foetal outcomes vs large cohort of unselected pregnancies
- No differences except for caesarian section
Hydroxychloroquine (HCQ) use
- Pregnancies with HCQ, prevalence differing by maternal diagnosis
- 58.3%
Original publication
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