Lupus & antiphospholipid syndrome
Primary antiphospholipid syndrome as a cause of impaired left ventricular diastolic function: experience from a Serbian cohort
Authors' conclusion
Thrombotic PAPS patients are at higher risk of LVDD development.
Study context
- Population
- Patients with primary APS (Serbian cohort) and healthy age- and sex-matched controls
- Participants
- 101 vs 90
- Exposure
- Primary APS vs healthy controls
- Primary antiphospholipid syndrome (PAPS)n = 101
- Healthy controlsn = 90reference
- Outcome
- LV diastolic dysfunction (LVDD): more than half of septal E′<7 cm/sec, lateral E′<10 cm/sec, average E/E′ >14, LA volume index (LAVI) >34 mL/m², peak tricuspid regurgitation velocity >2.8 m/sec abnormal
Methodological detailsage and sex-matched controls
- Age and sex-matched controls
Main finding
As reported in the abstract
LVDD prevalence
P = 0.001
Observational data: associations, not effects.
Further findings
LAVI · higher in PAPS
P = 0.012
- Isovolumic relaxation time, lateral E′ velocity, E/E′ ratio
- P = 0.0001
- Isovolumic relaxation time, lateral E′ velocity, E/E′ ratio
- P = 0.020
- Isovolumic relaxation time, lateral E′ velocity, E/E′ ratio
- P = 0.038
Factors related to left ventricular diastolic dysfunction (LVDD) in PAPS
- Age
- P = 0.0001
- BMI
- P = 0.008
- Hyperlipidaemia
- P = 0.039
- Thromboses
- P = 0.001
- Lupus anticoagulant (LAC) positivity
- P = 0.047
- Multivariate: thromboses significant, independent predictors of LVDD
Original publication
Primary antiphospholipid syndrome as a cause of impaired left ventricular diastolic function: experience from a Serbian cohort. Clin Exp Rheumatol. Published 13 January 2022. doi:10.
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