Lupus & antiphospholipid syndrome
Alpha-Klotho protein in systemic lupus erythematosus
Authors' conclusion
α-Klotho protein serum levels do not differ between patients with SLE and controls.
Study context
- Population
- Women with systemic lupus erythematosus (SLE) and sex- and age-matched controlsall women
- Participants
- 364 women
- Exposure
- SLE vs sex- and age-matched controls
- SLEn = 195
- Controlsn = 169reference
- Outcome
- Serum α-Klotho levels, SLE vs controls
Methodological detailssex- and age-matched controls, multivariable analysis
- Sex- and age-matched controls
- Multivariable analysis
Main finding
As reported in the abstract
Serum α-Klotho levels
- No differences in α-Klotho levels between SLE and controls, in univariable and multivariable analyses
Observational data: associations, not effects.
Further findings
α-Klotho and SLE features (SLE patients)
- SLE duration, acute phase reactants, activity, severity and damage indices, and autoantibody profile not significantly associated with serum α-Klotho
- Prednisone use and musculoskeletal manifestations significantly related to higher serum α-Klotho
Original publication
Alpha-Klotho protein in systemic lupus erythematosus. Clin Exp Rheumatol. Published 26 December 2021. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →