Lupus & antiphospholipid syndrome
Low-density granulocytes are related to shorter pregnancy duration but not to interferon alpha protein blood levels in systemic lupus erythematosus
Authors' conclusion
Our results suggest that SLE pregnancy results in increased peripheral granulocyte priming, and that higher LDG proportions late in pregnancy are related to shorter pregnancy duration but not to IFNα blood levels in SLE.
Study context
- Population
- Pregnant women with systemic lupus erythematosus (SLE) and healthy pregnant women, sampled in each trimester
- Participants
- 69 vs 27
- Exposure
- Pregnant women with SLE vs healthy pregnant women
- SLEn = 69
- HCn = 27reference
- Outcome
- LDG proportions, IFNα protein levels, granulocyte activation (CD62L shedding) and gestational age at birth
- Follow-up
- Throughout pregnancy
Methodological detailsrepeated sampling in trimesters one, two and three, late postpartum sampling
- Repeated sampling in trimesters one, two and three
- Late postpartum sampling
Main finding
As reported in the abstract
- Higher low-density granulocytes (LDG) proportions in SLE vs HC throughout pregnancy
- Increased IFNα protein levels in SLE vs HC throughout pregnancy
- Neither LDG fractions nor IFNα levels differed during pregnancy vs postpartum in SLE
- Granulocyte activation higher in SLE vs HC pregnancies, and increased during vs after pregnancy in SLE
- Higher LDG proportions in SLE associated with aPL positivity but not with IFNα protein levels
- Higher LDG proportions in trimester three correlated independently with lower gestational age at birth in SLE
Observational data: associations, not effects.
Original publication
Low-density granulocytes are related to shorter pregnancy duration but not to interferon alpha protein blood levels in systemic lupus erythematosus. Arthritis Res Ther. Published 22 June 2023. doi:10.
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