Lupus & antiphospholipid syndrome
Neuropsychiatric lupus in late- and early-onset systemic lupus erythematosus patients: a systematic review and meta-analysis
Pooled result · Cumulative NPSLE frequencyResult — go to the resultOdds ratio 1.41 95% CI 1.24–1.59Authors' conclusion
Our meta-analysis revealed that the frequencies of overall NPSLE, seizures, and psychosis were less common in late-onset SLE patients than in early-onset SLE patients.
Study context
- Population
- SLE patients in studies (English, 1959–2022) including a late-onset SLE comparison group and evaluating NPSLE frequency44 studies
- Participants
- 17,865 vs 2,970
- Comparison
- Early-onset vs late-onset SLE
- Early-onsetn = 17,865
- Late-onsetn = 2,970reference
- Outcome
- Cumulative NPSLE frequency
Methodological detailsCNS involvement reported in 3326 patients
- CNS involvement reported in 3326 patients
Pooled result
As reported in the abstract
Odds ratio
1.41
95% CI 1.24–1.59
P < 0.0001
Early-onsetvs Late-onset
OR 1.41 (95% CI 1.24–1.59); P < 0.0001
Further pooled results
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Seizures | 1.68 (1.27–2.22) | 0.0003 | |
| Psychosis | 1.72 (1.23–2.41) | 0.0014 | |
| Peripheral neuropathyMore common in late-onset SLE | 0.64 (0.47–0.86) | P = 0.004 | |
| 0.512Odds ratio (log scale) |
Original publication
Neuropsychiatric lupus in late- and early-onset systemic lupus erythematosus patients: a systematic review and meta-analysis. Rheumatology (Oxford). Published 21 June 2023. doi:10.
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