Lupus & antiphospholipid syndrome
Correlation between the changes of brain amplitude of low-frequency fluctuation and cognitive impairment in patients with neuropsychiatric lupus
Authors' conclusion
Patients with NPSLE show different brain activity changes in different brain regions, and the abnormal brain regions are correlated with certain lupus antibodies, inflammatory factors, and cognitive assessment
Study context
- Population
- Patients with neuropsychiatric systemic lupus erythematosus (NPSLE) and healthy controls
- Participants
- 28 vs 22
- Exposure
- NPSLE vs healthy controls
- NPSLEn = 28
- Healthy controls (HC)n = 22reference
- Outcome
- Correlation of resting-state ALFF values with serological data and behavioral cognitive assessment scores
Methodological detailsprospective, resting-state functional MRI, case-control
- Prospective
- Resting-state functional MRI
- Case-control
Main finding
As reported in the abstract
- NPSLE: increased brain activity in insula, precentral gyrus and superior temporal gyrus; decreased in superior parietal gyrus
- Insula amplitude of low-frequency fluctuation (ALFF) positively correlated with anti-β2gp1 antibody; negatively with anti-nucleosome antibody and AVL-RC score
- Precentral gyrus ALFF negatively correlated with AVL-I
- Superior temporal gyrus ALFF negatively correlated with AVL-RC score
- Left superior parietal gyrus positively correlated with CRP
- Right superior parietal gyrus positively correlated with SLE Disease Activity Index; negatively with AVL-I score
Observational data: associations, not effects.
Further findings
Baseline and cognitive characteristics
- NPSLE older on average than HC
- Significant differences in education level, AVLT-H and Trail Making Test scores between groups
Original publication
Correlation between the changes of brain amplitude of low-frequency fluctuation and cognitive impairment in patients with neuropsychiatric lupus. Lupus. Published 25 January 2024. doi:10.
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