Lupus & antiphospholipid syndrome
Analysis of clinical, immunological characteristics, damage, and survival in 300 Turkish systemic lupus erythematosus patients
Authors' conclusion
Ethnicity and geography influence the clinical diversity of SLE.
Study context
- Population
- Systemic Lupus Erythematosus (SLE) patients of Caucasian ethnicity diagnosed 2001–2017 at Kocaeli University Rheumatology Clinic, Turkey
- Participants
- 300 patients
- Outcome
- Clinical, immunological characteristics, damage and survival
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
- Female
- 89%
- Mean age of disease onset (SD 13.3), years
- 35.4
- Hematological manifestations
- 72.6%
- Mucocutaneous manifestations
- 72%
- Arthritis
- 66.3%
- Anti-dsDNA antibodies
- 61.6%
- Hypocomplementemia
- 57%
- Secondary APS
- 15.3%
- Lupus Nephritis (LN)
- 40.3%
- Class IV LN (most common pathologic finding)
- 30.5%
- Chronic kidney disease (CKD) (n = 13); 4 had renal replacement therapies
- 4.3%
- At least one damage parameter (musculoskeletal most common)
- 32.6%
- Malignancies, patients (cervical cancer most common, 4 cases)
- 13
- 5-year survival
- 92.5%
- 10-year survival
- 86.7%
Observational data: associations, not effects.
Further findings
Manifestations of secondary APS
- DVT
- 32.6%
- Cerebrovascular accidents
- 30.4%
Females vs males: mucocutaneous features
- Females had higher frequency of photosensitivity
- P = 0.019
- Females had higher frequency of malar rash
- P < 0.001
- Females had higher frequency of alopecia
- P = 0.014
Treatment in patients with LN
- Higher usage of pulse steroids, AZA, MMF, CYC and RTX in LN
- P < 0.001 for each
Juvenile-onset SLE (n = 31, 10.3%) (subgroup)
- Increased malar rash
- P = 0.009
- Increased nephritis
- P = 0.034
- Increased hypocomplementemia
- P = 0.001
- Increased positive anti-dsDNA
- P = 0.007
- Increased anti-Sm
- P = 0.046
- Increased anti-rib-P
- P = 0.014
Survival in patients with CKD
- Survival at 3 years
- 75%
- Survival at 15 years
- 60%
- CKD and history of infections associated with decreased survival (regression analysis)
- P = 0.02, each
Original publication
Analysis of clinical, immunological characteristics, damage, and survival in 300 Turkish systemic lupus erythematosus patients. Lupus. Published 23 January 2024. doi:10.
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