Lupus & antiphospholipid syndrome
High-density lipoprotein cholesterol subfraction HDL2 is associated with improved endothelial function in systemic lupus erythematosus
Authors' conclusion
HDL 2, a large HDL particle, was independently associated with greater FMD and may be a biomarker of vascular health in SLE.
Study context
- Population
- Adult patients with systemic lupus erythematosus (SLE) without known cardiovascular risk factors or disease
- Participants
- 41 patients
- Outcome
- Association of high-density lipoprotein (HDL)/LDL subfractions with brachial FMD
Methodological detailsconsecutive patients, machine learning models
- Consecutive patients
- Machine learning models
Main finding
As reported in the abstract
Median flow-mediated dilatation (FMD) (IQR 5.00%)
4.48%
Univariate: lower LDL1 associated with higher log-transformed FMD (r)
r=−0.313
p<0.05
Univariate: higher HDL2 associated with higher log-transformed FMD (r)
r=0.313
p<0.05
Multiple linear regression: HDL2 independent predictor of higher FMD, adjusted for age, BMI, LDL1 and systolic blood pressure (β, SE=0.012)
β=0.024
p<0.05
Observational data: associations, not effects.
Further findings
Common carotid artery (CCA) intima-media thickness (IMT)
- Median IMT (IQR 0.12 mm)
- 0.54 mm
- Age, low-density lipoprotein (LDL) cholesterol and systolic blood pressure independently associated with higher CCA IMT after adjusting for BMI and HDL2
Machine learning prediction of FMD (HDL2 positive association, prednisolone dose, LDL cholesterol, LDL1)
- Model prediction of FMD
- r=0.433, p<0.01
Original publication
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