Lupus & antiphospholipid syndrome
The increase of monocyte/high-density lipoprotein cholesterol ratio precedes recurrent thrombosis in patients with APS
Authors' conclusion
Our findings suggest that MHR increases in the 6 months preceding recurrent thrombotic events in APS patients
Study context
- Population
- Patients diagnosed with APS at Hokkaido University Hospital (median age at diagnosis 46 [31–56] years)median follow-up 14.4 years
- Participants
- 107 patients
- Exposure
- MHR at diagnosis in patients with vs without thrombotic recurrence; MHR 0-6 vs 6-36 months before recurrence
- Recurrencen = 31
- Outcome
- MHR at APS diagnosis as predictor of recurrent thrombotic events
Methodological detailslongitudinal, single-centre
- Longitudinal
- Single-centre
Main finding
As reported in the abstract
MHR at diagnosis, median [IQR] · APS diagnosis
Recurrence
5.0
median · IQR 3.4–8.0
No recurrence
5.3
median · IQR 3.5–8.6
P = 0.57
Observational data: associations, not effects.
Further findings
| Outcome | 0-6 months prior | 6-36 months prior | P value |
|---|---|---|---|
| Average MHR before recurrent thrombosis, 0-6 vs 6-36 months prior (patients with recurrence) · 0-6 and 6-36 months before eventSignificantly higher in 0-6 months | 6.1 (IQR 4.3–8.3) | 5.1 (IQR 3.8–8.6) | P = 0.04 |
Recurrent thrombotic events by type
- Arterial events
- 22
- Venous events
- 9
Original publication
The increase of monocyte/high-density lipoprotein cholesterol ratio precedes recurrent thrombosis in patients with APS. Rheumatology (Oxford). Published 6 December 2025. doi:10.
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