Lupus & antiphospholipid syndrome
Recurrence of thrombosis in patients with primary antiphospholipid syndrome: emphasis on arterial events
Authors' conclusion
The number of previous thrombotic events and the intensity of anticoagulation are rethrombosis risk factors. An INR ranging 2.5-3.5 protects against re-thrombosis, including arterial events.
Study context
- Population
- Patients with thrombotic primary antiphospholipid syndrome (APS) under VKAs with ≥4 INR determinations per year in at least 1 yearmedian follow-up 6.4 years
- Participants
- 81 patients
- Exposure
- Risk factors for rethrombosis, incl. anticoagulation intensity
- No rethrombosisn = 64
- Rethrombosisn = 17
- Outcome
- Rethrombosis risk factors
Methodological detailsCox survival analysis, hazard function curves
- Cox survival analysis
- Hazard function curves
Main finding
As reported in the abstract
Risk factors for rethrombosis
No rethrombosis
64
events
Rethrombosis
17
events
Observational data: associations, not effects.
Further findings
Cumulative rethrombosis risk by INR intensity (H(t) curves)
- Cumulative risk higher with INR <2.5 than INR 2.5-3.5
Mean INR 2.2 to identify patients at risk of rethrombosis
- Sensitivity
- 0.82
- Specificity
- 0.20
- AUC
- 0.42
Original publication
Recurrence of thrombosis in patients with primary antiphospholipid syndrome: emphasis on arterial events. Clin Exp Rheumatol. Published 3 May 2025. doi:10.
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