Lupus & antiphospholipid syndrome
Peripheral macrovascular thrombosis in catastrophic antiphospholipid syndrome (CAPS): A descriptive analysis from the “CAPS Registry”
Authors' conclusion
Peripheral macrovascular thrombosis is a clinically relevant manifestation of CAPS, mainly presenting as deep vein thrombosis. Peripheral arterial thrombosis carried an elevated risk of major amputation, contributing substantially to long-term morbidity.
Study context
- Population
- Patients with CAPS in the international CAPS Registry
- Participants
- 843 patients
- Exposure
- CAPS episodes with vs without peripheral macrovascular thrombosis; arterial vs venous events
- With peripheral macrovascular thrombosisn = 280
- Outcome
- Peripheral macrovascular thrombosis: occurrence and characteristics
Methodological detailsinternational registry (CAPS Registry), univariate and multivariable analyses
- International registry (CAPS Registry)
- Univariate and multivariable analyses
Main finding
As reported in the abstract
Peripheral macrovascular thrombosis
| Group | Value | Venous | Arterial | Combined arterial-venous |
|---|---|---|---|---|
| With peripheral macrovascular thrombosis | 33.2% | 58.3% | 30.6% | 11.2% |
With peripheral macrovascular thrombosis
Value33.2%
Venous58.3%
Arterial30.6%
Combined arterial-venous11.2%
Observational data: associations, not effects.
Further findings
Clinical features by peripheral macrovascular thrombosis
- Male sex, CAPS as first APS manifestation, infection and malignancy as triggers, and pulmonary involvement significantly more frequent in episodes with peripheral macrovascular thrombosis
- Episodes without peripheral macrovascular thrombosis: higher rates of SLE, triple aPL positivity, laboratory features of thrombotic microangiopathy and multiorgan involvement
- Arterial thrombosis associated with older age
Mortality
- Did not differ significantly between groups
Safety
- Major amputations
- 28 (24% of episodes with peripheral arterial thrombosis)
Original publication
Peripheral macrovascular thrombosis in catastrophic antiphospholipid syndrome (CAPS): A descriptive analysis from the “CAPS Registry”. Semin Arthritis Rheum. Published 13 September 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →