Lupus & antiphospholipid syndrome
Long-term association of the triglyceride-glucose index with cardiovascular involvement in systemic lupus erythematosus: a retrospective cohort study
Authors' conclusion
These findings support the potential value of the TyG index as an accessible marker of cardiometabolic risk in SLE.
Study context
- Population
- Patients with SLE admitted between 2000 and 2021
- Participants
- 991 patients
- Exposure
- Per one-unit increase in the triglyceride-glucose index
- Outcome
- Cardiovascular involvement
Methodological detailsCox proportional hazards regression, restricted cubic spline analyses, Kaplan-Meier curves across triglyceride-glucose (TyG) quartiles
- Cox proportional hazards regression
- Restricted cubic spline analyses
- Kaplan-Meier curves across TyG quartiles
Main finding
As reported in the abstract
Overall cardiovascular involvement, per one-unit increase in TyG
Per one-unit increase in TyGHazard ratio (95% CI)
After accounting for non-proportional covariate effects
1.37(1.10–1.71)
Per one-unit increase in TyG, as printed
- After multivariable adjustment
- aHR 1.36; P < 0.05
- Cardiovascular involvement occurred (whole cohort)
- 251 (25.3%)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Inflammatory/lupus-related cardiovascular manifestations, per one-unit increase in TyGAfter accounting for non-proportional covariate effects | 1.35 (1.06–1.74) | |
| 0.512Hazard ratio (log scale) |
- Inflammatory/lupus-related cardiovascular manifestations, per one-unit increase in TyG — Inflammatory or lupus-related manifestations
- 210
Major adverse cardiovascular events (MACE) (original composite)
- MACE events
- 41
- Higher TyG associated with increased risk in adjusted analysis; less robust in post hoc sensitivity analysis excluding HF
- Interpret cautiously because of the limited number of events
Original publication
Long-term association of the triglyceride-glucose index with cardiovascular involvement in systemic lupus erythematosus: a retrospective cohort study. Lupus Sci Med. Published 12 September 2026. doi:10.
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