Lupus & antiphospholipid syndrome
Integrated metabolomics and DNA methylation signatures and their association with flare remission in SLE
Authors' conclusion
Changes in chemical features, including confirmed metabolites bilirubin and adenosine, were associated with flare remission and changes in DNAm at SLE-relevant loci.
Study context
- Population
- Multiethnic patients with SLE recruited during a rheumatologist-confirmed flare, followed up 3 months later
- Participants
- 40 patients
- Exposure
- Remitters vs non-remitters at 3-month follow-up
- Remittersn = 16
- Outcome
- Chemical features whose change between visits was associated with remission at follow-up
- Follow-up
- 3 months
Methodological detailsuntargeted metabolomics, DNA methylation (Illumina EPIC array), time × remission interaction (limma), adjusted for follow-up time and medications
- Untargeted metabolomics
- DNA methylation (Illumina EPIC array)
- Time × remission interaction (limma), adjusted for follow-up time and medications
Main finding
As reported in the abstract
Chemical features associated with remission
62
Assigned a putative consensus chemical formula
19
Adenosine (confirmed with reference standard), interaction coefficient β 95% CI 1.44 to 3.14
2.29
Bilirubin (confirmed with reference standard), interaction coefficient β 95% CI 1.09 to 2.94
2.02
Observational data: associations, not effects.
Further findings
Correlations between changes in significant chemical features and DNA methylation (DNAm) at 291 remission-associated sites
- Significantly correlated chemical feature-DNAm pairs (p<0.05/62×291)
- 23
- Adenosine vs EBF1 DNAm, r (p=1.35×10-7)
- −0.77
- Adenosine vs IL12B DNAm, r (p=1.87×10-6)
- 0.69
- Adenosine vs GRAMD1C DNAm, r (p=1.00×10-6)
- −0.71
- Adenosine strongly correlated with four DNAm sites, three within immune-related genes
Original publication
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