Lupus & antiphospholipid syndrome
Identification and functional characterisation of SCO1 as a mitochondria-related biomarker in lupus nephritis
Authors' conclusion
SCO1 showed elevated expression in renal tubules and strong discriminatory ability.
Study context
- Population
- Gene expression datasets of lupus nephritis (LN) (Gene Expression Omnibus) and HK-2 cells
- Comparison
- LN vs healthy controls
Methodological detailsbioinformatic analysis of GEO and MitoCarta3.0 data, WGCNA, PPI network and random forest modelling, immunofluorescence and functional assays in HK-2 cells
- Bioinformatic analysis of GEO and MitoCarta3.0 data
- WGCNA, PPI network and random forest modelling
- Immunofluorescence and functional assays in HK-2 cells
Main finding
As reported in the abstract
- 36 mitochondrial DEGs (MitoDEGs); SCO1 identified as hub MitoDEG
- SCO1 showed strong discriminatory power in both training and validation sets
- SCO1 significantly positively correlated with CD8+T cells, naive CD4+T cells and resting memory CD4+T cells (after FDR correction)
- SCO1 predominantly expressed in renal tubules and significantly upregulated in LN vs healthy controls
- SCO1 overexpression enhanced cell viability; knockdown reduced viability, increased mitochondrial ROS and decreased mitochondrial membrane potential, without affecting ATP levels
- SCO1 modulation altered P62 expression but did not significantly affect PARKIN, PINK1 or LC3B levels
Original publication
Identification and functional characterisation of SCO1 as a mitochondria-related biomarker in lupus nephritis. Lupus Sci Med. Published 12 September 2026. doi:10.
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