Lupus & antiphospholipid syndrome
Outcome of critically ill patients with systemic lupus erythematosus from a medical intensive care unit in Southern India
Authors' conclusion
The mortality of SLE patients admitted to the ICU in this study is high, and infections were the principal reason for death.
Study context
- Population
- Patients with systemic lupus erythematosus (SLE) (ACR/SLICC 2012) admitted to a medical intensive care units (ICU) in Southern India, 2011–202172 retrospective, 30 prospective
- Participants
- 30 vs 30
- Exposure
- SLE-ICU vs non-ICU SLE
- SLE-ICUn = 30
- Non ICU-SLEn = 30reference
- Outcome
- Mortality at 90 days (prospective); hospital discharge or death in hospital (retrospective)
- Follow-up
- 90 days
Methodological detailsretrospective and prospective enrolment, single-centre, multivariable analysis
- Retrospective and prospective enrolment
- Single-centre
- Multivariable analysis
Main finding
As reported in the abstract
Death
Patients who died
83
81.3%
Deaths due to infections
54
Deaths due to SLE related causes
29
Observational data: associations, not effects.
Further findings
HDL · day 1
P = 0.045
Procalcitonin (ng/mL) · day 1
P < 0.001
Procalcitonin (ng/mL) · day 5
P = 0.004
Predictors of non-survival (multivariable analysis)
- APACHE-II >16
- P = 0.026
- Lymphopenia
- P = 0.021
- Infection
- P = 0.002
- Creatinine >1.3 mg/dL
- P = 0.023
- Hypotension requiring vasopressor support
- P = 0.006
Respiratory causes as indication for ICU admission
- Respiratory causes
- 78/102 (76.5%)
Original publication
Outcome of critically ill patients with systemic lupus erythematosus from a medical intensive care unit in Southern India. Lupus. Published 28 September 2023. doi:10.
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