Lupus & antiphospholipid syndrome
Persisting mortality gap in systemic lupus erythematosus; a population-based study on juvenile- and adult-onset SLE in Norway 1999–2022
Main finding · SMR, incident adult-onset SLEResult — go to the resultSMR 1.8 95% CI 1.6–2.2Authors' conclusion
This study shows persistence of a mortality gap between adult-onset SLE and controls at population level and provides indications of worryingly high mortality in juvenile-onset SLE.
Study context
- Population
- All chart review-confirmed SLE cases resident in Southeast Norway (population 2.9 million) 1999–2017, followed to death, emigration or 1 October 2022749 incident, met 2019-EA criteria
- Participants
- 1,558 participants
- Exposure
- SLE vs matched population controls
- Incident adult-onset SLEn = 749
- Juvenile-onset SLEn = 93
- Outcome
- Mortality (SMR) and survival rates
Methodological details15 population controls per case matched for age, sex, residency and ethnicity, Kaplan-Meier, Cox regression
- 15 population controls per case matched for age, sex, residency and ethnicity
- Kaplan-Meier
- Cox regression
Main finding
SMR, incident adult-onset SLE
Standardized mortality rate (SMR)
1.8
95% CI 1.6–2.2
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | SMR (95% CI) |
|---|---|
| Long-term SMR in total Nor-SLE cohort, juvenile-onset SLEJuvenile-onset SLE vs Matched controls | 7.2 (3.3–14) |
- Long-term SMR in total Nor-SLE cohort, juvenile-onset SLE: SMR peaked in juvenile-onset SLE and fell gradually by increasing age at SLE diagnosis
Risk factors for survival (multivariable analysis)
- LN associated with decreased survival, while sex did not
Original publication
Persisting mortality gap in systemic lupus erythematosus; a population-based study on juvenile- and adult-onset SLE in Norway 1999–2022. Rheumatology (Oxford). Published 28 September 2023. doi:10.
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