Lupus & antiphospholipid syndrome
Sensitivity of classification criteria from time of diagnosis in an incident systemic lupus erythematosus cohort: a population-based study from Norway
Authors' conclusion
Showing 92% criteria fulfilment already at time of SLE diagnosis by 2019 EULAR/ACR criteria versus 77% by 1997 ACR criteria, the results from this population-based study suggest that the 2019 EULAR/ACR criteria will achieve its goal of capturing more early-SLE cases for clinical trials.
Study context
- Population
- Incident systemic lupus erythematosus (SLE) cases ICD-10 coded 2000–2017 and confirmed by expert clinical assessment, Nor-SLE cohort, Southeast Norway (2.9 million inhabitants)701 adults · 36 juveniles
- Participants
- 737 participants
- Exposure
- 2019 EULAR/ACR vs 1997 ACR classification criteria for SLE
- Outcome
- Sensitivity of classification criteria
- Follow-up
- At diagnosis
Methodological detailsincident cohort, individual case review
- Incident cohort
- Individual case review
Main finding
As reported in the abstract
P < 0.001
Observational data: associations, not effects.
Further findings
Sensitivity in juveniles (<16 years) · At diagnosis
Sensitivity in juveniles (<16 years) · At diagnosis
- 2019 EULAR/ACR not more sensitive than 1997 ACR for juveniles
2019 EULAR/ACR counts at diagnosis by age group and ethnicity
- Higher in young cases and those originating from Asia
2019 EULAR/ACR fulfilment rate in adult females, diagnosis to study end · Study end (mean disease duration 7.5 years)
- At diagnosis
- 92.5%
- At study end
- 94.6%
2019 EULAR/ACR fulfilment rate in adult males, diagnosis to study end · Study end (mean disease duration 7.5 years)
- At diagnosis
- 86.5%
- At study end
- 91.0%
Original publication
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