Lupus & antiphospholipid syndrome
Circulating extracellular vesicles in Systemic Lupus Erythematosus: physicochemical properties and phenotype
Authors' conclusion
Plasma-circulating EVs from patients with SLE with and without nephritis are increased in peripheral blood and have different physicochemical properties than controls.
Study context
- Population
- Adult female patients with SLE, with or without Lupus Nephritis (LN), and healthy controls
- Exposure
- SLE vs healthy controls
- SLEn = 38
- Controlsn = 18reference
- Outcome
- Physicochemical and phenotypic characteristics of plasma-circulating EVs and their potential utility as disease biomarkers
Methodological detailscase-control, healthy controls matched by gender and similar age
- Case-control
- Healthy controls matched by gender and similar age
Main finding
As reported in the abstract
Circulating EV characteristics, SLE vs controls
- SLE-EVs reached larger diameters than Ctrl-EVs
- p<0.0001
- Small SLE-EVs increased vs Ctrl-EV
- p<0.0001
- Large SLE-EVs increased vs Ctrl-EV
- p<0.05
- Higher concentrations of large Extracellular Vesicles (EVs), LN vs controls
- p<0.001
- Higher concentrations of large EVs, nLN vs controls
- p<0.0001
- Different Energy Dispersion Spectrum (EDS), SLE-EVs vs Ctrl-EVs
- p<0.001
- SLE-EVs less electronegative than Ctrl-EVs
- p<0.0001
- EV-CD45+ more frequent in SLE vs controls
- p<0.001
- EV-CD14+ more frequent in SLE vs controls
- p<0.05
- EV-IgM+ more frequent in SLE vs controls
- p<0.001
Observational data: associations, not effects.
Original publication
Circulating extracellular vesicles in Systemic Lupus Erythematosus: physicochemical properties and phenotype. Lupus Sci Med. Published 17 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →