Lupus & antiphospholipid syndrome
Effects of systemic lupus erythematosus on the brain: a systematic review of structural MRI findings and their relationships with cognitive dysfunction
Authors' conclusion
Advanced structural MRI analysis can identify total and regional brain abnormalities associated with CD in patients with SLE, with potential to enhance clinical assessment.
Study context
- Population
- Patients with systemic lupus erythematosus (SLE), with and without clinically diagnosed CNS involvement, in studies reporting advanced structural or diffusion MRI metrics and evaluating cognitive dysfunction18 studies
- Outcome
- Relationship between structural and diffusion MRI metrics and cognitive dysfunction in SLE
Methodological detailsPRISMA guidelines, retrospective and prospective studies, Databases searched January 2000 to October 2023
- PRISMA guidelines
- Retrospective and prospective studies
- Databases searched January 2000 to October 2023
Pooled result
As reported in the abstract
Included studies: 8 structural MRI, 9 diffusion MRI, 1 with both modalities
18
Sample sizes of participants with SLE per study, range
11 to 120
Original publication
Effects of systemic lupus erythematosus on the brain: a systematic review of structural MRI findings and their relationships with cognitive dysfunction. Lupus Sci Med. Published 17 August 2024. doi:10.
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