Lupus & antiphospholipid syndrome
Utility of pan-immune-inflammation value as a predictor of the prognosis of childhood lupus
Authors' conclusion
Our work suggests the PIIV might be a reasonable predictor for organ involvement and disease activity in newly diagnosed cSLE
Study context
- Population
- Childhood SLE (cSLE) patients meeting EULAR/ACR-19 criteria, immunosuppressive drug-naïve at diagnosis, minimal follow-up 12 months, participating centres January 2010–December 2022104 female
- Participants
- 125 patients
- Outcome
- Disease activity (SLEDAI-2K) and organ involvement predicted by PIIV at diagnosis
- Follow-up
- 12 months
Methodological detailsobservational, multicentre
- Observational
- Multicentre
Main finding
As reported in the abstract
Prediction of disease activity, PIIV cut-off 250
| Group | Cut-off | Sensitivity | Specificity |
|---|---|---|---|
| Pan-immune inflammation value (PIIV) | 250 | 45% | 86% |
Pan-immune inflammation value (PIIV)
Cut-off250
Sensitivity45%
Specificity86%
Observational data: associations, not effects.
Further findings
| Outcome | Values |
|---|---|
| PIIV at diagnosis | PIIV median 139 (IQR 229.6) |
SLEDAI at diagnosis and 12 months
- Median SLEDAI at diagnosis
- 12 (IQR 6.5)
- Median SLEDAI at 12 months
- 3.5 (IQR 7.0)
Most frequent organ involvement at 12 months
- Renal
- 40.0%
- Hematological
- 39.2%
- Musculoskeletal
- 15.2%
- Mucocutaneous
- 10.4%
Original publication
Utility of pan-immune-inflammation value as a predictor of the prognosis of childhood lupus. Lupus. Published 16 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →