Lupus & antiphospholipid syndrome
Urine Proteomics Link Complement Activation with Interstitial Fibrosis/Tubular Atrophy in Lupus Nephritis Patients
Authors' conclusion
This study identified C3, CFI, and C9-to-CD59 ratio as potential markers of tubulointerstitial fibrosis in LN.
Study context
- Population
- Adult and paediatric biopsy-proven lupus nephritis (LN) patients with clinically indicated kidney biopsies, 2010–201941 (89.1%) women
- Participants
- 46 participants
- Exposure
- LN with moderate/severe interstitial fibrosis and tubular atrophy (IFTA) vs none/mild IFTA
- Moderate/severe IFTAn = 10
- Outcome
- Urinary C9-to-CD59 ratio and individual urinary complement components
Methodological detailsurine proteomics (mass spectrometry)
- Urine proteomics (mass spectrometry)
Main finding
As reported in the abstract
Urinary C9-to-CD59 ratio
Moderate/severe IFTA
0.91
median · IQR 0.83–1.05
None/mild IFTA
0.81
median · IQR 0.76–0.91
P = 0.01
Observational data: associations, not effects.
Further findings
| Outcome | Moderate/severe IFTA | None/mild IFTA | P value |
|---|---|---|---|
| Urinary C3Median | 24.4 (IQR 23.5–25.5) | 20.2 (IQR 18.5–22.2) | P = 0.02 |
| Urinary CFIMedium | 28.8 (IQR 21.8–30.6) | 20.4 (IQR 18.5–22.9) | P = 0.01 |
Correlation of urinary complement with fibrosis mediators
- Complement C9, CD59, C3 and CFI correlated with TGFβR1, PDGFβ, and PDGFRβ, while C9, CD59 and C3 correlated with TGFβR2
Original publication
Urine Proteomics Link Complement Activation with Interstitial Fibrosis/Tubular Atrophy in Lupus Nephritis Patients. Semin Arthritis Rheum. Published 27 September 2023. doi:10.
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