Lupus & antiphospholipid syndrome
Association between interstitial fibrosis/tubular atrophy (IFTA) on kidney biopsies and anti Ro60 antibody positivity in patients with lupus nephritis (LN)
Authors' conclusion
In this biopsy-based LN cohort, Ro60 positivity was associated with a consistent trend toward more severe IFTA, with a statistically significant association in sensitivity analysis excluding one severe outlier case.
Study context
- Population
- Adults with biopsy-confirmed LN at a single academic center
- Participants
- 16 vs 25
- Exposure
- Ro60-positive vs Ro60-negative
- Ro60-positiven = 16
- Ro60-negativen = 25reference
- Outcome
- IFTA severity (none, mild, moderate, severe) graded by a renal pathologist
Methodological detailssingle-centre, ordinal logistic regression, multivariable proportional odds model
- Single-centre
- Ordinal logistic regression
- Multivariable proportional odds model
Main finding
As reported in the abstract
IFTA severity (ordinal: none, mild, moderate, severe), Ro60 positivity
Ro60 positivityOdds ratio (95% CI)P value
Univariable analysis
3.05(0.86–11.5)
P = 0.087Multivariable model, 29 complete cases
2.76(0.77–13.04)
P = 0.127Observational data: associations, not effects.
Further findings
IFTA severity, Black race
| OR (95% CI) | P value | ||
|---|---|---|---|
| Black raceUnivariable analysis | 7.82 (1.02–93.12) | P = 0.014 | |
| Black raceMultivariable model, 29 complete cases | 8.06 (0.92–275.61) | P = 0.015 | |
| 0.050.21520Odds ratio (log scale) |
IFTA severity, class IV LN (multivariable)
| OR (95% CI) | P value | ||
|---|---|---|---|
| Class IV LN | 1.90 (0.37–13.24) | P = 0.371 | |
| 0.050.21520Odds ratio (log scale) |
IFTA severity, sensitivity analysis excluding the single severe IFTA case
| OR | P value | |
|---|---|---|
| Ro60 positivity | 5.25 | P = 0.028 |
| Black race | 15.79 | P = 0.005 |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Association between interstitial fibrosis/tubular atrophy (IFTA) on kidney biopsies and anti Ro60 antibody positivity in patients with lupus nephritis (LN). Lupus. Published 16 April 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →