Lupus & antiphospholipid syndrome
Reasons for ICU admissions and mortality in systemic lupus erythematosus in a South Indian tertiary centre - An observational study
Authors' conclusion
The leading cause of admission to ICU in our cohort was high disease activity with or without concomitant infection. The mortality rate in our study population was 29%, which is in line with the observed trend in the last 2 decades. APACHE II score at presentation, need for RRT, and baseline serum lactate emerged as independent predictors of ICU mortality.
Study context
- Population
- Patients with SLE admitted to ICU for any cause, 2015–2021, tertiary care hospital in South India87% female
- Participants
- 87 patients
- Outcome
- Reasons for ICU admission among patients with SLE
Methodological detailssingle-centre, tertiary care hospital, Data from medical records; descriptive statistics and logistic regression for in-hospital mortality
- Single-centre
- Tertiary care hospital
- Data from medical records; descriptive statistics and logistic regression for in-hospital mortality
Main finding
As reported in the abstract
High disease activity with infection
48%
High disease activity alone
39%
Observational data: associations, not effects.
Secondary outcomes
Independent predictors of mortality (multivariate model excluding cardiac arrest)
| OR (95% CI) | P value | ||
|---|---|---|---|
| APACHE II scoreMultivariate model excluding cardiac arrest | 1.56 (1.14–2.17) | P = 0.010 | |
| RRTMultivariate model excluding cardiac arrest | 7.41 (2.86–20.00) | P < 0.001 | |
| LactateMultivariate model excluding cardiac arrest | 1.06 (1.01–1.10) | P = 0.009 | |
| 0.050.21520Odds ratio (log scale) |
Overall (in-hospital) mortality rate
- Overall mortality rate, infection and disease activity major contributors
- 29%
Admission scores and ICU LOS
- APACHE II score, mean ± SD
- 17.32 ± 6.42
- SLEDAI-2K score, mean ± SD
- 15.16 ± 8.3
- Duration of ICU stay, mean ± SD (days)
- 6.02 ± 6.58
Original publication
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