Lupus & antiphospholipid syndrome
Comparison of clinicopathological characteristics and outcomes between patients with late and early-onset systemic lupus erythematosus with lupus nephritis: A North African study
Authors' conclusion
Our results indicate that SLE patients have different clinical, serological and histological manifestations depending on the age at onset of the disease.
Study context
- Population
- Patients with lupus nephritis (LN) admitted to a nephrology unit between 2007 and 2024, North Africa
- Participants
- 231 patients
- Exposure
- Late-onset systemic lupus erythematosus (SLE) vs early-onset SLE with LN
- Late-onset SLEn = 43
- Early-onset SLEn = 188reference
- Outcome
- Clinicopathological characteristics and outcomes of LN
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
- No difference in time from SLE diagnosis to LN
- Late-onset: higher prevalence of discoid rash, lower frequency of leukopenia
- Late-onset: higher serum creatinine, lower prevalence of anti-SSA and anti-RNP antibodies
- Class VI LN significantly more frequent in late-onset
- Oral GC, HCQ and immunosuppressive drug use significantly lower in late-onset
- Early-onset significantly less likely to progress to CKD
Observational data: associations, not effects.
Further findings
Mean age at SLE diagnosis
Original publication
Comparison of clinicopathological characteristics and outcomes between patients with late and early-onset systemic lupus erythematosus with lupus nephritis: A North African study. Lupus. Published 26 August 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →