Lupus & antiphospholipid syndrome
Expression and significance of TWEAK and CD163 in monocytes of patients with newly diagnosed systemic lupus erythematosus with renal involvement
Authors' conclusion
The expression levels of TWEAK and CD163 are increased in SLE patients, and the expression levels in SLE+RI patients are greater than those in SLE-RI patients. These findings are closely related to disease activity, autoantibody production and clinical symptoms and can be used as biomarkers for the diagnosis and activity of SLE+RI.
Study context
- Population
- Patients with systemic lupus erythematosus (SLE), including SLE with renal involvement (SLE+RI)70 SLE patients
- Comparison
- TWEAK and CD163 expression in monocytes: SLE vs healthy controls and rheumatoid arthritis (RA)
- SLEn = 70
- Outcome
- Expression levels of TWEAK and CD163 in peripheral blood monocytes and their diagnostic value for SLE and SLE+RI
Methodological detailsRT-qPCR, ROC curve analysis, Western blot
- RT-qPCR
- ROC curve analysis
- Western blot
Performance
As reported in the abstract
Diagnostic accuracy for SLE+RI (ROC)
| Test or model | AUC |
|---|---|
| TWEAK | 0.869 |
| CD163 | 0.792 |
| TWEAK + CD163 | 0.842 |
AUC
TWEAK0.869
CD1630.792
TWEAK + CD1630.842
Further findings
| Outcome | P value |
|---|---|
| TWEAK and CD163 expression after vs before treatment in SLE+RISignificantly lower after treatment | P < 0.05 |
TWEAK and CD163 expression by anti-double-stranded DNA antibody (anti-dsDNA) and proteinuria status
- Greater in anti-dsDNA-positive vs anti-dsDNA-negative patients and in patients with vs without proteinuria
Correlation with SLEDAI in SLE+RI
- TWEAK and CD163 expression positively correlated with SLEDAI
TWEAK and CD163 protein expression (Western blot) in SLE+RI
- Significantly increased vs controls
Original publication
Expression and significance of TWEAK and CD163 in monocytes of patients with newly diagnosed systemic lupus erythematosus with renal involvement. Lupus. Published 25 August 2025. doi:10.
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