Lupus & antiphospholipid syndrome
Systemic lupus erythematosus (SLE) classification criteria item relationships: implications on SLE as a disease entity
Authors' conclusion
This comprehensive analysis of relationships between the domains and items of the EULAR/ACR SLE classification criteria underlines the relevance of the domain structure. Overall, the data are more compatible with chance distribution than with fixed subsets of SLE.
Study context
- Population
- Patients with SLE; EULAR/American College for Rheumatology (ACR) classification criteria domains and items analysed as binary variables (ever present = 1, always absent = 0)
- Participants
- 1,196 patients
- Outcome
- Relationships between EULAR/ACR classification criteria domains and individual criteria items
Methodological detailscluster analysis, network analysis
- Cluster analysis
- Network analysis
Main finding
As reported in the abstract
Relevant correlations between items within domains; some significant, mostly weak associations between items of different domains (r)
0.10 to 0.26
Observational data: associations, not effects.
Original publication
SLE classification criteria item relationships: implications on SLE as a disease entity. Ann Rheum Dis. Published 22 August 2025. doi:10.
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