Lupus & antiphospholipid syndrome
Advancing treat-to-target in SLE: a pilot study using a clinical decision support system
Authors' conclusion
Implementation of a T2T strategy supported by a CDSS in SLE outpatient care was feasible, usable and acceptable to patients and physicians.
Study context
- Population
- Adult patients with SLE in routine outpatient care, four rheumatology outpatient centres35 completed
- Participants
- 38 patients
- Comparison
- Treat-to-target (T2T) strategy supported by a Clinical Decision Support System (CDSS) vs routine outpatient care
- Outcome
- Feasibility (recruitment and retention rates), usability (System Usability Scale, physicians) and acceptability (Treatment Satisfaction Questionnaire, qualitative feedback)
- Follow-up
- 24 weeks
Methodological detailsnon-randomised, multicentre, clustered, allocated by centre, 24-week
- Non-randomised
- Multicentre
- Clustered
- Allocated by centre
- 24-week
Main finding
As reported in the abstract
Feasibility, usability and acceptability
Recruitment rate (38 of 91 screened enrolled)
42%
Retention rate (35 completed)
92%
System Usability Scale (SUS) score for the CDSS (physicians in T2T-CDSS), indicating good usability
73.8
Further findings
Remission achieved at least once (exploratory)
Treatment intensifications and de-escalations (exploratory)
Treatment intensifications (exploratory)
Treatment de-escalation (GC tapering) (exploratory)
Remission achieved at least once (exploratory)
- No statistically significant differences between groups in disease activity outcomes or remission rates
Original publication
Advancing treat-to-target in SLE: a pilot study using a clinical decision support system. Lupus Sci Med. Published 22 August 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →