Lupus & antiphospholipid syndrome
Longitudinal observation of thrombotic events in patients with obstetric antiphospholipid syndrome
Authors' conclusion
Thrombotic events may occur in OAPS patients even decades after diagnosis of OAPS, particularly in those with high-risk aPL profiles and conventional thrombotic risk factors.
Study context
- Population
- Female patients with antiphospholipid syndrome (APS) and obstetric manifestations diagnosed at Hokkaido University Hospital, 2004–202447 female APS patients
- Participants
- 23 / 24 / 4 / 9
- Exposure
- APS with vs without history of thrombosis at diagnosis; Obstetric antiphospholipid syndrome (OAPS) cases with new thrombotic events vs event-free controls >10 years
- Thromboticn = 23
- Non-thromboticn = 24reference
- Casesn = 4
- Controlsn = 9reference
- Outcome
- Long-term thrombotic outcomes in OAPS initially without thrombosis
Methodological detailssingle-centre, cross-sectional comparison, nested case-control study
- Single-centre
- Cross-sectional comparison
- Nested case-control study
Main finding
As reported in the abstract
First thrombotic event during long-term follow-up in OAPS without prior thrombosis · median of 16 years after the diagnosis
Non-thrombotic
4
events
Observational data: associations, not effects.
Further findings
| Outcome | Thrombotic | Non-thrombotic | P value |
|---|---|---|---|
| Prevalence of SLEThrombotic vs Non-thrombotic | 74% | 40% | P = 0.019, Fisher's exact test |
Triple aPL positivity and conventional thrombotic risk factors
- More frequent among cases than controls
Original publication
Longitudinal observation of thrombotic events in patients with obstetric antiphospholipid syndrome. Lupus. Published 23 June 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →