Lupus & antiphospholipid syndrome
Improvement of high-density lipoprotein atheroprotective properties in patients with systemic lupus erythematosus after belimumab treatment
Authors' conclusion
HDL of SLE patients with active disease displays impaired atheroprotective properties accompanied by distinct lipidomic signatures compared with controls.
Study context
- Population
- Systemic Lupus Erythematosus (SLE) patients with active disease despite conventional therapy, and matched healthy individuals
- Participants
- 35 / 35 / 26
- Comparison
- SLE patients before vs after 6-month add-on belimumab; SLE patients vs matched healthy individuals
- SLE before belimumabn = 35reference
- SLE after belimumabn = 35
- Healthy individualsn = 26
- Outcome
- HDL atheroprotective properties (cholesterol efflux and antioxidant capacities, PON1 activity, serum amyloid A1 (SAA1), myeloperoxidase (MPO), lipid peroxidation products) and HDL lipidome
- Follow-up
- 6 months
Methodological detailsbefore-and-after 6-month add-on treatment, matched healthy controls
- Before-and-after 6-month add-on treatment
- Matched healthy controls
Main finding
As reported in the abstract
HDL atheroprotective properties after belimumab
- High-density lipoprotein (HDL) cholesterol efflux and antioxidant capacities significantly increased after belimumab and restored to levels of control subjects
- HDL-associated PON1 activity increased after treatment
- Lipid peroxidation products decreased after treatment
- HDL cholesterol efflux and antioxidant capacities correlated negatively with disease activity
- Changes in HDL lipidome after belimumab and between SLE patients and healthy individuals; specific lipid species changes correlated with HDL functional parameters
Original publication
Improvement of high-density lipoprotein atheroprotective properties in patients with systemic lupus erythematosus after belimumab treatment. Rheumatology (Oxford). Published 21 March 2024. doi:10.
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