Lupus & antiphospholipid syndrome
Immunoglobulin G/immunoglobulin M autoantibody ratios in incomplete systemic lupus erythematosus
Authors' conclusion
IgG anti-dsDNA, anti-Ro52, anti-Ro60, and IgM anti-dsDNA were elevated in iSLE and SLE patients, which was not apparent from the respective IgG/IgM ratios only. IgG/IgM autoantibody ratios remained relatively stable over up to 5 years in iSLE non-progressors and six patients who progressed to SLE.
Study context
- Population
- Patients with incomplete systemic lupus erythematosus (iSLE), patients with systemic lupus erythematosus (SLE), and healthy controls
- Participants
- 34 / 41 / 11
- Exposure
- iSLE vs SLE vs healthy controls
- iSLEn = 34
- SLEn = 41
- Healthy controls (HCs)n = 11reference
- Outcome
- IgG/IgM autoantibody ratios (anti-dsDNA, anti-Ro52, anti-Ro60) between groups, and their relation to progression from iSLE to SLE
Main finding
As reported in the abstract
IgG/IgM autoantibody ratios at baseline
- Immunoglobulin G (IgG)/immunoglobulin M (IgM) anti-dsDNA and anti-Ro52 ratios similar between groups
- IgG/IgM anti-Ro60 ratios significantly elevated in iSLE and SLE vs HCs
- IgG anti-dsDNA, anti-Ro52, anti-Ro60, and IgM anti-dsDNA elevated in iSLE and SLE
Observational data: associations, not effects.
Further findings
Correlation of IgG/IgM ratios with interferon signature and clinical parameters
- Not correlated with interferon signature or clinical parameters
IgG/IgM ratios over follow-up in iSLE non-progressors vs progressors to SLE · median follow-up of 18 months
- Similar at baseline and relatively stable in non-progressors and six iSLE patients who progressed to SLE
Original publication
Immunoglobulin G/immunoglobulin M autoantibody ratios in incomplete systemic lupus erythematosus. Scand J Rheumatol. Published 20 March 2024. doi:10.
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